3D-Printed Human Embryonic Stem Cells Created for First Time

Imagine if you could take living cells, load them into a printer, and squirt out a 3D tissue that could develop into a kidney or a heart. Scientists are one step closer to that reality, now that they have developed the first printer for embryonic human stem cells.

In a new study, researchers from the University of Edinburgh have created a cell printer that spits out living embryonic stem cells. The printer was capable of printing uniform-size droplets of cells gently enough to keep the cells alive and maintain their ability to develop into different cell types. The new printing method could be used to make 3D human tissues for testing new drugs, grow organs, or ultimately print cells directly inside the body.

Human embryonic stem cells (hESCs) are obtained from human embryos and can develop into any cell type in an adult person, from brain tissue to muscle to bone. This attribute makes them ideal for use in regenerative medicine — repairing, replacing and regenerating damaged cells, tissues or organs. [Stem Cells: 5 Fascinating Findings]

In a lab dish, hESCs can be placed in a solution that contains the biological cues that tell the cells to develop into specific tissue types, a process called differentiation. The process starts with the cells forming what are called “embryoid bodies.” Cell printers offer a means of producing embryoid bodies of a defined size and shape.

In the new study, the cell printer was made from a modified CNC machine (a computer-controlled machining tool) outfitted with two “bio-ink” dispensers: one containing stem cells in a nutrient-rich soup called cell medium and another containing just the medium. These embryonic stem cells were dispensed through computer-operated valves, while a microscope mounted to the printer provided a close-up view of what was being printed.

The two inks were dispensed in layers, one on top of the other to create cell droplets of varying concentration. The smallest droplets were only two nanoliters, containing roughly five cells.

The cells were printed onto a dish containing many small wells. The dish was then flipped over so the droplets now hung from them, allowing the stem cells to form clumps inside each well. (The printer lays down the cells in precisely sized droplets and in a certain pattern that is optimal for differentiation.)

Tests revealed that more than 95 percent of the cells were still alive 24 hours after being printed, suggesting they had not been killed by the printing process. More than 89 percent of the cells were still alive three days later, and also tested positive for a marker of their pluripotency — their potential to develop into different cell types.

Biomedical engineer Utkan Demirci, of Harvard University Medical School and Brigham and Women’s Hospital, has done pioneering work in printing cells, and thinks the new study is taking it in an exciting direction. “This technology could be really good for high-throughput drug testing,” Demirci told LiveScience. One can build mini-tissues from the bottom up, using a repeatable, reliable method, he said. Building whole organs is the long-term goal, Demirci said, though he cautioned that it “may be quite far from where we are today.”

Others have created printers for other types of cells. Demirci and colleagues made one that printed embryonic stem cells from mice. Others have printed a kind of human stem cells from connective tissues, which aren’t able to develop into as many cell types as embryonic stem cells. The current study is the first to print embryonic stem cells from humans, researchers report in the Feb. 5 issue of the journal Biofabrication.

Follow LiveScience on Twitter @livescience. We’re also on Facebook & Google+.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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What follows N. Korea's nuclear test?

STORY HIGHLIGHTS

• Lopez: Uranium-based blast would pose new challenge to U.N. Security Council


• Indicates Pyongyang has advanced centrifuge technologies and related systems


• North Korea's young leader appears to care little about what U.N. or China think


• Product-based sanctions may stifle the North's ability to continue nuclear program

Editor's note: George A. Lopez holds the Hesburgh Chair in Peace Studies at the Kroc Institute, University of Notre Dame. He is a former member, U.N. Panel of Experts on North Korea, or the Democratic People's Republic of Korea (DPRK).

Indiana, U.S. (CNN) -- North Korea will soon test its third nuclear device. Earlier tests in 2006 and 2009 drew worldwide condemnation, Security Council sanctions and led Pyongyang to withdraw from the six-party talks.

In resolution 2087, passed on January 22, the Council imposed new sanctions on North Korea for its December 12 space missile launch and made clear that new violations would be dealt with harshly.

READ: N.Korea: Close to nuclear missile?

In response, North Korea rejected Council legitimacy, asserted their right to nuclear weapons and deterrence and proclaimed it would soon conduct a new nuclear test.

In addition the North engaged in some strong saber-rattling aimed at South Korea.

READ: For South Koreans, a familiar tone from Pyongyang

Because some analysts believe this will be a uranium explosion, it is a game-changer for the region and poses new and unfavorable challenges to the Security Council. A successful uranium test indicates that Pyongyang has advanced centrifuge technologies and related support systems. It means that North Korea, if left unchecked, can both produce and export such material, raising new concerns that Pyongyang and Iran cooperate in such developments.

Politically the test will reveal that the new regime of Kim Jong-Un exceeds the defiance to U.N. dictates of his predecessors in pursuing his nation's nuclear goals. Neither the prospect of stronger sanctions, nor the growing discontent of Russia and China with his behavior, appears to deter North Korea's young leader.

OPINION: Rescind North Korea's license to provoke

These dilemmas confront the permanent five members of the Council with a harsh reality check regarding their unity of action and what message to convey to the north via what particular sanctions. If the Council follows the logic of resolution 2087, it will impose more extensive and punishing sanctions than ever before. Such sanctions will blacklist companies, government agencies and individuals long known for their role in illicit technology procurement and sanctions evasion. They will expand financial sanctions into areas of banking that would require substantial transnational enforcement to bite, and they may call upon countries in the region to inspect almost all North Korean trade. The economic squeeze and further isolation of the DPRK will increase substantially.

READ: Why sticks don't work with North Korea

These sanctions would require China to play an enforcement role against North Korean economic actors it has hitherto resisted. Seizing prohibited goods that pass through Dalian harbor and other trans-shipment points, as well as shutting down various border activities, would also fall to China. These extensive sanctions as punishment operate from the assumption that at some point the north will forego its nuclear program in order to survive as an authoritarian state.

But there may be an alternative to the punishment approach that could bring Beijing on board with effective Council action. China might well accept specialized trade sanctions aimed to degrade the DPRK's ability to sustain the nuclear program for lack of material and due to prohibitive costs of sanctions busting, as a way of conveying to Pyongyang that it must return to the negotiating table.

The logic of extensive new product-focused sanctions is that DPRK can make -- or jerry-rig -- only a small fraction of the advanced technologies and specialty materials that sustain an ongoing uranium enrichment program. To choke off these materials -- and the illicit means of financing them -- provides the Council with a possibility to make it technically impossible for DPRK to have a functioning uranium-based bomb program.

Precise lists of dozens of the materials used in centrifuge operation that should be sanctioned are already recorded for the Council in the reports of their Panel of Experts for the DPRK. Lists of related materials have also been developed by the Nuclear Supplies Group. To date the permanent five have sanctioned only a very few of the materials on either list. The Council also needs member states to strengthen export, customs and financial controls on dual-use items that are "below grade" of those newly sanctioned items. This will stifle the North's ability to upgrade or jerry-rig these hitherto unsanctioned items as a way of maintaining their program.

READ: Five things to know about North Korea's planned nuclear test

Also critical to the success of this choking of supplies would be stricter controls of the illicit financing that supports such trade. Putting strong enforcement behind the 2087 resolution's concern about DPRK cash flows, especially through its embassies, is also in order.

Another, somewhat unprecedented, sanctions option would be a Council-issued travel ban on North Korea placed on all scientists, engineers and others with specialized expertise in centrifuge technologies and uranium enrichment.

Political agreement on these measures will not be easy to attain among the permanent five nations of the Security Council. But a product-focused sanctions approach -- especially leveraged to aim for more direct diplomatic engagement with the DPRK while denying them material to grow their illicit programs -- has the best chance of gaining Council consensus.

The opinions expressed in this commentary are solely those of George A. Lopez.

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3 dead in West Side crash

A man and two women died in a crash on the city's West Side, authorities said.

Firefighters were called to the accident near 31st Street and Western Avenue about 8:30 p.m., according to the department's media office.

Fire officials cut three people out of a red Jeep after the car lost control and somehow ended up on it's top just west of Western Avenue on 31st Street, police  said.

Three people had been riding in the SUV and all were taken to Mount Sinai Hospital and pronounced dead there, police said. They were the only occupants in the SUV.

Just before 10 p.m., the radio in the SUV -- which was flipped on its top -- could still be heard faintly from a distance.

The SUV was eastbound on 31st Street when it hit a curb, then a light pole, and ended up on its roof, Chicago Police News Affairs Officer Hector Alfaro said.

"Some of the damage is from the fire department," police said of the doors, which had been cut to free the car's occupants. "But they flipped the car themselves.

Investigators from the department's Major Accidents Investigations Unit arrived at the scene Thursday night to investigate what had happened.

Three people were taken to Mount Sinai Hospital, one in "extremely critical" condition, two in critical condtion, according to the fire department.

The three were identified as: Phillip Barnes, of the 1500 block of Ludington Circle in Romeoville, Yvonne Tobias of the 400 block of South Homan Avenue in Chicago, and Leantwana Rosebur of the 4900 block of South Gladys Avenue in Chicago.

Barnes, 46, was pronounced dead at 9:20 p.m. Tobias, 57, was pronounced dead at 9:09 p.m. Roseburr, 40, was pronounced dead at 9:19 p.m.

Video from the scene showed a red Jeep flipped over, with its roof crushed, and a person wrapped in black on a stretcher being taken into an ambulance.

chicagobreaking@tribune.com

Twitter: @ChicagoBreaking

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Tsunami kills at least five in Solomons after big Pacific quake

(Reuters) - A powerful 8.0 magnitude earthquake set off a tsunami that killed at least five people in a remote part of the Solomon Islands on Wednesday and triggered evacuations across the South Pacific as island nations issued tsunami alerts.

The quake struck 340 km (211 miles) east of Kira Kira in the Solomons, the Pacific Tsunami Warning Center in Hawaii said as it issued warnings for the Solomons and other South Pacific nations including Australia and New Zealand. It later canceled the warnings for the outlying regions.

A tsunami measuring 0.9 metres (three feet) hit near the town of Lata on the remote Santa Cruz island, swamping some villages and the town's main airport as people fled to safety on higher ground.

More than three dozen aftershocks up to magnitude 6.6 rocked the region in the hours after the quake, the U.S. Geological Survey said.

Lata hospital's director of nursing, Augustine Pilve, told New Zealand television that five people had been killed, including a boy about 10 years old, adding that more casualties were possible as officials made their way to at least three villages that may have been hit.

"It's more likely that other villages along the coast of Santa Cruz may be affected," he said.

Disaster officials in the Solomon Islands capital Honiara told the Solomon Islands Broadcasting Corp. that they believed six people were dead and that five villages had suffered damage.

Solomon Islands Police Commissioner John Lansley said it was too early to fully assess the damage or casualty numbers, and said authorities hoped to send aircraft to the region on Thursday to help determine the extent of the damage.

Luke Taula, a fisheries officer in Lata, said he watched the tsunami as it came in small tidal surges rather than as one large wave.

"We have small waves come in, then go out again, then come back in. The waves have reached the airport terminal," he told Reuters by telephone.

The worst damage was to villages on the western side of a point that protects the main township, he said.

"There are reports that some communities have been badly hit, their houses have been damaged by the waves."

About 5,000 people lived in and around the town, but the area was deserted as people fled to higher ground, Taula said.

HOT SPOT

The Solomons, perched on the geologically active "Pacific Ring of Fire", were hit by a devastating tsunami following an 8.1 magnitude quake in 2007. At least 50 people were killed then and dozens left missing and more than 13 villages destroyed.

"It's an area that is very prone to earthquakes," said Jonathan Bathgate, seismologist at Geoscience Australia. "We've had seven 6-plus magnitude earthquakes in this region since January 31, so it has been very active in the past week."

Initial signs were that the tremor was a thrust quake, in which vertical movement in the continental plates generates higher risk of tsunami, Bathgate added.

Authorities in the Solomons, Fiji, Guam and elsewhere had urged residents to higher ground before the Pacific Tsunami Warning Center canceled its alerts.

"The earthquake would have to be quite a bit bigger to make a much more sizeable tsunami," said Brian Shiro, geophysicist for the center in Hawaii.

(Reporting by James Grubel in CANBERRA,; Additional reporting by Michael Perry and Lincoln Feast in SYDNEY and Alex Dobuzinskis in LOS ANGELES)

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Stock futures indicate rebound from recent sell-off

NEW YORK (Reuters) -Stock index futures advanced on Tuesday, indicating that Wall Street would rebound off its worst daily session since November.

* Major averages dropped about 1 percent on Monday, pressured by renewed worries over the euro zone's sovereign debt crisis. While the day's decline pushed the S&P 500 into negative territory for February, equities have been strong performers of late, and the benchmark index is up 4.9 percent for 2013.

* Wall Street has advanced on strong fourth-quarter earnings and signs of improved economic growth, suggesting the market's longer-term trend remains higher.

* Archer Daniels Midland , Walt Disney Co and Kellogg Co are among the companies on tap to report on Tuesday. According to Thomson Reuters data, of the 256 S&P 500 companies that have reported earnings thus far, 68.4 percent have beaten profit expectations, compared with the 62 percent average since 1994 and the 65 percent average over the past four quarters.

* S&P 500 fourth-quarter earnings are expected to rise 4.4 percent, according to the data. That estimate is above the 1.9 percent forecast at the start of earnings season, but well below the 9.9 percent forecast on October 1.

* On Tuesday, S&P 500 futures rose 7.2 points and were above fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures added 69 points and Nasdaq 100 futures rose 11.5 points.

* At current levels, the S&P is about 5.4 percent away from its all-time intraday high of 1,576.09, reached in October 2011.

* Investors will also be looking to the Institute for Supply Management's January non-manufacturing index, due at 10 a.m. Economists forecast a reading of 55.2, versus 55.7 in December.

* Last week, the ISM's manufacturing index for January showed the pace of growth in manufacturing picked up to its highest level in nine months.

* In company news, McGraw-Hill will be in focus a day after news the U.S. Justice Department plans to sue the company's Standard & Poor's unit over its mortgage bond ratings. The action would mark the first such federal action against a credit rating agency related to the recent financial crisis.

* The stock plummeted almost 14 percent in Monday's session, its worst daily losses since the October 1987 market crash.

* Dell Inc may also be volatile as the company moved closer to a nearly $24 billion buyout deal to take the company private. The stock rose 1.1 percent to $13.42 in light premarket trading.

(Editing by W Simon)

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Niners have better chance than Ravens to be back

NEW ORLEANS (AP) — The Baltimore Ravens carried off the Lombardi Trophy. Their beaten opponent has a better chance of doing it next season.

San Francisco running back Frank Gore insisted the 49ers were the more talented team even after losing 34-31 to the Ravens in Sunday's Super Bowl. The scoreboard said otherwise, but when the conference champions meet at the Meadowlands next February — yes, outdoors in the dead of winter for the NFL crown — the Niners easily could represent the NFC.

Again.

"I'd say we've got a great group of guys in the locker room, great warriors," Gore said, "and I'm not going to promise anything next year, but we're going to fight to get back here."

The toughest fight might be in their own division with Seattle and rapidly improving St. Louis. The Seahawks were the only team to allow fewer points than the 49ers, and their rivalry — including the semi-feud between coaches Jim Harbaugh and Pete Carroll — adds spice to the NFC West.

But the 49ers have to be the NFC favorite after losing in overtime to the Giants for the conference title last year, then barely falling to the Ravens on Sunday night.

"This is kind of tough, to get this far and let everything slip away through your hands," said Ahmad Brooks, part of the best linebacking corps in the league, along with All-Pros Patrick Willis, Aldon Smith and NaVorro Bowman. "The funny thing about it is, within the next few months, we're going to start trying to get back to the same place that we're at right now."

As will the Ravens, but their challenge is more imposing.

Unlike the 49ers, who figure to lose virtually no important parts — receiver Randy Moss, perhaps, but he was a marginal player in 2012 — the Ravens have bid adieu to their greatest player, linebacker Ray Lewis. Not only will they miss his performances on the field and his presence in the locker room, but he was the emotional engine in Baltimore.

The leadership burden will fall on two players whose contracts have expired but likely will be back with the Ravens: Super Bowl MVP quarterback Joe Flacco and veteran safety Ed Reed.

Flacco almost certainly will get the franchise tag at more than $14 million if he can't agree to a long-term deal. But in the current NFL, winning without a top-level QB is impossible, and there can be no arguing now about Flacco belonging in that class.

Reed wants to return and the Ravens recognize how unwise it would be to let both Lewis and Reed leave at the same time — even after winning their second Super Bowl in 12 seasons.

"I always said when I came into the league and got drafted that I didn't want to be one of those guys jumping from team to team," Reed said during Super Bowl week.

Regardless, the Ravens will be a force — odds makers have placed them behind New England and Denver in the AFC next season — and one of the NFL's most prolific offensive teams.

Flacco throwing to the superb trio of wide receivers Anquan Boldin and Torrey Smith and tight end Dennis Pitta, plus the versatility of running back Ray Rice and a stud backup in Bernard Pierce says so. Flacco's protection from the line and All-Pro fullback Vonta Leach was impeccable in the postseason, helping Flacco throw for a record-tying 11 TDs with no interceptions.

The defense, oddly enough considering Baltimore's reputation, needs some work. But linebacker Terrell Suggs will be even healthier — he came back quickly from a torn Achilles tendon — and top cornerback Lardarius Webb returns from a knee injury.

Just like the 49ers, the Ravens have a tough task in their division. Cincinnati is young, but has made the playoffs the last two years. Pittsburgh never remains dormant for long.

Should these two clubs make it to the first outdoor Super Bowl at a cold-weather site, would Baltimore have the edge because it's used to such conditions? And because it's a three-hour drive from MetLife Stadium, will Ravens fans be out in force even more than they were in the Big Easy?

Or would the 49ers' immense talent base be overwhelming?

Food for thought over the next 11 months.

"We've got to look at this as a blessing because we didn't have to be here, but we made it," tight end Vernon Davis said. "We've always got next year; we've got next season. We might as well look forward to next season, keep our hopes high and continue to climb."

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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Richard III still the criminal king

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

Richard III on stage and screen

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STORY HIGHLIGHTS

• Dan Jones: Richard III's remains found; some see chance to redeem his bad reputation


• Jones says the bones reveal and confirm his appearance, how he died and his injuries


• Nothing changes his rep as a usurper of the Crown who likely had nephews killed, Jones says


• Jones: Richard good or bad? Truth likely somewhere in between

Editor's note: Dan Jones is a historian and newspaper columnist based in London. His new book, "The Plantagenets" (Viking) is published in the US this Spring. Follow him on Twitter.

(CNN) -- Richard III is the king we British just can't seem to make our minds up about.

The monarch who reigned from 1483 to 1485 became, a century later, the blackest villain of Shakespeare's history plays. The three most commonly known facts of his life are that he stole the Crown, murdered his nephews and died wailing for a horse at the Battle of Bosworth in 1485. His death ushered in the Tudor dynasty, so Richard often suffers the dual ignominy of being named the last "medieval" king of England -- in which medieval is not held to be a good thing.

Like any black legend, much of it is slander.

Richard did indeed usurp the Crown and lose at Bosworth. He probably had his nephews killed too -- it is unknowable but overwhelmingly likely. Yet as his many supporters have been busy telling us since it was announced Monday that Richard's lost skeleton was found in a car park in Leicester, he wasn't all bad. In fact, he was for most of his life loyal and conscientious.

Dan Jones

To fill you in, a news conference held at the University of Leicester Monday confirmed what archaeologists working there have suspected for months: that a skeleton removed from under a parking lot in the city center last fall was indeed the long-lost remains of Richard III.

His official burial place -- under the floor of a church belonging to the monastic order of the Greyfriars -- had been lost during the dissolution of the monasteries that was carried out in the 1530s under Henry VIII. A legend grew up that the bones had been thrown in a river. Today, we know they were not.

What do the bones tell us?

Well, they show that Richard -- identified by mitochondrial DNA tests against a Canadian descendant of his sister, Anne of York -- was about 5-foot-8, suffered curvature of the spine and had delicate limbs. He had been buried roughly and unceremoniously in a shallow grave too small for him, beneath the choir of the church.

He had died from a slicing blow to the back of the head sustained during battle and had suffered many other "humiliation injuries" after his death, including having a knife or dagger plunged into his hind parts. His hands may have been tied at his burial. A TV show aired Monday night in the UK was expected to show a facial reconstruction from the skull.

Opinion: What will the finding of Richard III mean?

In other words, we have quite a lot of either new or confirmed biographical information about Richard.

He was not a hunchback, but he was spindly and warped. He died unhorsed. He was buried where it was said he was buried. He very likely was, as one source had said, carried roughly across a horse's back from the battlefield where he died to Leicester, stripped naked and abused all the way.

All this is known today thanks to a superb piece of historical teamwork.

The interdisciplinary team at Leicester that worked toward Monday's revelations deserves huge plaudits. From the desk-based research that pinpointed the spot to dig, to the digging itself, to the bone analysis, the DNA work and the genealogy that identified Richard's descendants, all of it is worthy of the highest praise. Hat-tips, too, to the Richard III Society, as well as Leicester's City Council, which pulled together to make the project happen and also to publicize the society and city so effectively.

However, should anyone today tell you that Richard's skeleton somehow vindicates his historical reputation, you may tell them they are talking horsefeathers.

Richard III got a rep for a reason. He usurped the Crown from a 12-year old boy, who later died.

This was his great crime, and there is no point denying it. It is true that before this crime, Richard was a conspicuously loyal lieutenant to the boy's father, his own brother, King Edward IV. It is also true that once he was king, Richard made a great effort to promote justice to the poor and needy, stabilize royal finances and contain public disorder.

But this does not mitigate that he stole the Crown, justifying it after the fact with the claim that his nephews were illegitimate. Likewise, it remains indisputably true that his usurpation threw English politics, painstakingly restored to some order in the 12 years before his crime, into a turmoil from which it did not fully recover for another two decades.

So the discovery of Richard's bones is exciting. But it does not tell us anything to justify changing the current historical view of Richard: that the Tudor historians and propagandists, culminating with Shakespeare, may have exaggerated his physical deformities and the horrors of Richard's character, but he remains a criminal king whose actions wrought havoc on his realm.

Unfortunately, we don't all want to hear that. Richard remains the only king with a society devoted to rehabilitating his name, and it is a trait of some "Ricardians" to refuse to acknowledge any criticism of their hero whatever. So despite today's discovery, we Brits are likely to remain split on Richard down the old lines: murdering, crook-backed, dissembling Shakespearean monster versus misunderstood, loyal, enlightened, slandered hero. Which is the truth?

Somewhere in between. That's a classic historian's answer, isn't it? But it's also the truth.

Follow us on Twitter @CNNOpinion.

Join us on Facebook/CNNOpinion.

The opinions expressed in this commentary are solely those of Dan Jones.

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Chicago, your commute will likely take far longer than you think

You can predict with a high degree of confidence that the time it takes to drive from Point A to B on any given day is unpredictable.

And it's not just snowy or rainy days. It can be any day.

If there is a bright side, it's that Chicago was not the worst.

Residents of the Chicago area are accommodating that increasing uncertainty by setting aside more time each day — just in case — for the commute, new research shows.

For the most important trips, such as going to work, medical appointments, the airport or making a 5:30 p.m. pickup at the child care center to avoid late fees, drivers in northeastern Illinois and northwest Indiana should count on allotting four times as much time as it would take to travel in free-flowing traffic, according to the "Urban Mobility Report" to be released Tuesday by the Texas A&M Transportation Institute. The analysis is based on 2011 data, which are the most recent available.

It is the first time that travel reliability was measured in the 30-year history of the annual report. The researchers created a Planning Time Index geared toward helping commuters reach their destinations on time in more than 95 percent of the trips. A second index, requiring less padding of travel time, would get an employee to work on time four out of five days a week.

"If you plan only for average traffic conditions on your trip in the Chicago area, you are going to be late at least half the time," said Bill Eisele, a senior research engineer at the Transportation Institute who co-authored the study.

The constant unreliability that hovers over commuting is stealing precious time from other activities, crimping lifestyles, causing mounting frustration for drivers and slapping extra costs on businesses that rely on just-in-time shipments to manage inventory efficiently, researchers found.

The Chicago region ranked No. 7 among very large urban areas and 13th among 498 U.S. cities on a scale of the most unreliable highway travel times. The Washington area was the worst. A driver using the freeway system in the nation's capital and surrounding suburbs should budget almost three hours to complete a high-priority trip that would take only 30 minutes in light traffic, the study said.

The Washington area was followed on the list by the metropolitan areas of Los Angeles, New York-Newark, Boston, Dallas-Fort Worth, and Seattle.

Rounding out the top 10, the Chicago metro area was trailed by San Francisco-Oakland, Atlanta, and Houston.

Truck driver Frank Denk said he usually adds an hour or two to his trip through the Chicago area. Sometimes, it's not enough, other times traffic isn't a problem, he said. The one constant, Denk said Monday afternoon while taking a break at the O'Hare Oasis on the Tri-State Tollway, is that it is almost impossible to anticipate correctly.

"Job-wise, it can be very detrimental to truckers," said Denk, who is based in Green Bay, Wis. "All of a sudden, you're not able to make your delivery."

But quadrupling the time to travel back and forth each day? That's excessive, said Mike Hennigan, a 64-year-old accountant who regularly commutes from his Evanston home to his office near the junction of the Kennedy and Edens expressways. He recommends doubling the anticipated travel time.

"I can predict when it's going to be bad," Hennigan said, although he is less optimistic about his travel times when he heads toward downtown.

"Coming into the Loop can be deadly, especially later in the week," Hennigan said.

Overall, traffic congestion in the Chicago region is getting worse as the economy improves, although it's not as severe as the grip that gridlock has taken recently on some other very large metropolitan areas in the U.S., according to the report. The Washington area again topped the list, followed by Los Angeles, San Francisco-Oakland, New York-Newark, Boston, Houston, Atlanta, Chicago, Philadelphia, and Seattle.

No longer being ranked at the very top of the congestion heap provides little consolation for Chicago-area drivers.

What should be a 20-minute jaunt across town in Chicago or the suburbs if highway capacity were sufficient to permit vehicles to travel the speed limit now becomes about an 80-minute ordeal, according to the Texas A&M study. Scheduling 80 minutes for the trip would ensure an on-time arrival 19 out of 20 times, the study concluded.

But that would be similar to treating every day of the year as if it were like Monday, when a moderate snowfall blanketing the Chicago region smacked traffic into slow motion during the morning rush.

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Iran's Ahmadinejad in Egypt on historic visit

CAIRO (Reuters) - President Mahmoud Ahmadinejad arrived in Egypt on Tuesday on the first trip by an Iranian head of state since the 1979 revolution, underlining the thaw in relations since Egyptians elected an Islamist head of state.

President Mohamed Mursi, the Muslim Brotherhood politician elected in June, kissed Ahmadinejad as he disembarked from his plane at Cairo airport. The leaders walked down a red carpet, Ahmadinejad smiling as he shook hands with waiting dignitaries.

Visiting Cairo to attend an Islamic summit that begins on Wednesday, the president of the Shi'ite Islamist republic is due to meet later on Tuesday with the grand sheikh of al-Azhar, one of the oldest seats of learning in the Sunni world.

Such a visit would have been unthinkable during the rule of Hosni Mubarak, the military-backed autocrat who preserved Egypt's peace treaty with Israel during his 30 years in power and deepened ties between Cairo and the West.

"The political geography of the region will change if Iran and Egypt take a unified position on the Palestinian question," Ahmadinejad said in an interview with Al Mayadeen, a Beirut-based TV station, on the eve of his visit.

He said he wanted to visit the Gaza Strip, the Palestinian territory which neighbors Egypt to the east and is run by the Islamist movement Hamas. "If they allow it, I would go to Gaza to visit the people," Ahmadinejad said.

Analysts doubt that the historic changes that brought Mursi to power in Egypt will result in a full restoration of diplomatic ties between states whose relations were broken off after the Iranian revolution and the conclusion of Egypt's peace treaty with Israel in 1979.

OBSTACLES TO FULL TIES

At the airport the two leaders discussed ways of boosting relations between their countries and resolving the Syrian crisis "without resorting to military intervention", Egyptian state media reported.

Egypt is concerned by Iran's support for Syrian President Bashar al-Assad, who is trying to crush an uprising inspired by the revolt that swept Mubarak from power two years ago. Egypt's overwhelmingly Sunni Muslim population is broadly supportive of the uprising against Assad's Alawite-led administration.

The Mursi administration also wants to safeguard relations with Gulf Arab states that are supporting Cairo's battered state finances and are deeply suspicious of Iran. Mursi wants to preserve ties with the United States, the source of $1.3 billion in aid each year to the influential Egyptian military.

Mursi's government has established close ties with Hamas, a movement backed by Iran and shunned by the West because of its hostility to Israel, but its priority is addressing Egypt's deep economic problems.

"The restoration of full relations with Iran in this period is difficult, despite the warmth in ties ... because of many problems including the Syrian crisis and Cairo's links with the Gulf states, Israel and the United States," said one former Egyptian diplomat.

Speaking to Reuters on the sidelines of preparatory meetings for the two-day Islamic summit, Iranian Foreign Minister Ali Akbar Salehi said he was optimistic that ties could grow closer.

"We are gradually improving. We have to be a little bit patient. I'm very hopeful about the expansion of the bilateral relationship," he said. Asked where he saw room for closer ties, he said: "Trade and economics."

Ahmadinejad's visit to Egypt follows Mursi's visit to Iran in August for a summit of the Non-Aligned Movement.

Sheikh Ahmed al-Tayeb, head of the 1,000-year-old al-Azhar mosque and university, will meet Ahmadinejad at his offices in mediaeval Islamic Cairo, al-Azhar's media office said.

Salehi, the Iranian foreign Minister, stressed the importance of Muslim unity when he met Sheikh al-Tayeb at al-Azhar last month.

Egypt and Iran have taken opposite courses since the late 1970s. Egypt, under Mubarak's predecessor Anwar Sadat, concluded a peace treaty with Israel in 1979 and became a close ally of the United States and Europe. Iran from 1979 turned into a center of opposition to Western influence in the Middle East.

Symbolically, Iran named a street in Tehran after the Islamist who led the 1981 assassination of Sadat.

Egypt gave asylum and a state funeral to Iran's exiled Shah Reza Pahlavi, who was overthrown by the 1979 Iranian revolution. He is buried in a medieval Cairo mosque alongside his ex-brother-in-law, Egypt's last king, Farouk.

(Additional reporting by Ayman Samir; Editing by Andrew Roche)

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European political worries halt risk asset rally

London (Reuters) - Stronger U.S. and Chinese economic data supported world equity markets on Monday, while the euro dipped and Spanish bond yields rose as growing political uncertainty in southern Europe worried investors.

The global economic outlook brightened substantially last week when data showed U.S. factory activity quickened in January and hiring increased, and a euro zone business activity survey suggested the worst of the region's downturn may be over.

On Sunday China said its official purchasing managers' index (PMI) for the services sector had risen for a fourth straight month in January, although its slim gain added to evidence that the global recovery is a modest one.

But in Europe the uncertainties in Spain and Italy reminded investors of the risks still ahead, dampening the positive mood and encouraging some sellers.

Over the weekend Spain's opposition Socialist Party called on Prime Minister Mariano Rajoy to resign over a corruption scandal, as a poll showed the lowest support on record for his centre-right People's Party (PP).

"If Rajoy were really forced to resign, if we were to have new elections in Spain, that would not help the improvement we've seen in financial markets," Tobias Blattner, European economist at Daiwa Capital Markets said.

In Italy former prime minister Silvio Berlusconi, one of the top candidates in this month's general election, is seeing a resurgence in popularity which threatens the reforms implemented by the outgoing technocrat government.

Spanish 10-year government bond yields rose 10 basis points to 5.32 percent on Monday while equivalent Italian yields were 9 bps higher at 4.42 percent.

The yield gains reversed the strong start to the year on all of Europe's peripheral markets which had been helped by the easy supply of cash from central banks and the promise that the European Central Bank will buy bonds of struggling states if necessary.

However, the improving economic outlook was still supporting a shift out of safe-haven German government bonds, although the yield gains were tempered by the rise in Spanish and Italian debt. German 10-year bonds were up three basis points at 1.7 percent.

The uncertainty in Spain and Italy, along with more weak Spanish employment data, also drove the euro down against the dollar.

EURO SETBACK

The common currency fell 0.4 percent to $1.3574, off a high of $1.3710 on Friday which was its strongest level since late 2011.

Analysts said this was likely to be only a temporary setback, and the euro would resume its move higher if, as expected, the ECB leaves interest rates unchanged on Thursday and does not express any concerns about the recent gains.

"Once the ECB fails to cut rates on Thursday, which is our view, the euro will be free to move higher again, but with the uncertainty surrounding the meeting the euro will likely weaken slightly or trade sideways," said Adam Myers, senior FX strategist at Calyon.

Equity markets were looking to consolidate after the strong economic data last week had taken many market benchmark indexes to fresh multi-year highs.

EQUITY RECORDS

MSCI's world equity index <.miwd00000pus> rose just 0.1 percent on Monday, holding near a 23-month high and a few points shy of its best level since 2008.

The FTSEurofirst 300 index <.fteu3> of top European shares was little changed while Germany's DAX <.gdaxi> dipped 0.1 percent to 7,832 points but remained within sight of its 2007 all-time high of 8,151 points.

U.S. stocks were poised for a mixed start as well after the jobs and manufacturing data on Friday prompted buying that took the Dow Jones average above 14,000 for the first time since October 2007 <.dji>.

The benchmark S&P 500 index <.spx> also touched its highest since December 2007 after a 5 percent gain in January, which was its best start to a year since 1997. The index is now just about 60 points away from its all-time intraday high of 1,576.09

Rising confidence in the global economic recovery was also underpinning commodities such as oil and copper, although prices moved in narrow ranges at the start of a week when several major central banks hold policy meetings.

Brent crude was 35 cents lower at $116.41 per barrel though close to a 4-1/2 month high of $117.07 reached on Friday. U.S. crude slipped 45 cents to $97.32 per barrel

"The market is long due a correction. Still, there is no point standing in front of a moving train," VTB Capital oil strategist Andrey Kryuchenkov said.

(Additional reporting by Anooja Debnath; Editing by David Stamp)

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